Jendle J, Karlberg B E, Persliden J, Franzén L, Arborelius M
Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Sweden.
J Aerosol Med. 1995 Fall;8(3):243-54. doi: 10.1089/jam.1995.8.243.
This study describes the delivery and distribution of an aerosol generated by a jet nebulizer (MAXIN) in an experimental animal model. Anesthetised, intubated and ventilated piglets inhaled radiolabeled technetium diethylene-triamine-penta-acetic acid (99mTc-DTPA) through the endotracheal tube. The lungs were excised en bloc and scintigraphed, using a computerized gamma camera to evaluate the pattern of distribution. By nebulizing radiolabeled 125I-insulin and comparing the activity deposited on inspiratory and expiratory electrostatic filters, delivery and retention of nebulized insulin was assessed. The distribution of aerosol in the lungs was very even and reached the most peripheral parts. The delivery of nebulized insulin was calculated to be 88.9 +/- 5.3% and 36.1 +/- 8.8% of the insulin delivered to the respiratory tract was retained. The immediate local effects of insulin aerosol administration on the lungs were evaluated using light microscopy. No adverse effects were observed at histopathologic examination of the lung tissue.
This study shows a high penetration of aerosol to the peripheral parts of the lung and efficient delivery of nebulized insulin when using the MAXIN-nebulizer.
本研究描述了在实验动物模型中由喷射雾化器（MAXIN）产生的气溶胶的递送和分布情况。麻醉、插管并通气的仔猪通过气管内导管吸入放射性标记的锝二乙烯三胺五乙酸（99mTc-DTPA）。将肺整体切除并进行闪烁扫描，使用计算机化γ相机评估分布模式。通过雾化放射性标记的125I-胰岛素并比较沉积在吸气和呼气静电过滤器上的活性，评估雾化胰岛素的递送和滞留情况。气溶胶在肺内的分布非常均匀，且能到达最外周部分。计算得出雾化胰岛素的递送率为88.9±5.3%，递送至呼吸道的胰岛素有36.1±8.8%被滞留。使用光学显微镜评估了胰岛素气溶胶给药对肺的即时局部效应。在肺组织的组织病理学检查中未观察到不良反应。
本研究表明，使用MAXIN雾化器时，气溶胶对肺外周部分的穿透性高，雾化胰岛素的递送效率高。
