Miller R F, Jarritt P H, Lui D, Kidery J, Semple S J, Ell P J
Department of Medicine, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.
Eur J Nucl Med. 1991;18(3):164-70. doi: 10.1007/BF02262726.
We report the validation of a new delivery system--aerosol production equipment (known by the acronym APE), which generates a particulate aerosol of technetium 99m diethylene triamine penta-acetic acid (DTPA) with a mass-median aerodynamic diameter of 0.35 microns and a geometric standard deviation of 1.8 Twenty subjects were studied; in group 1 were 12 healthy men with normal spirometry; in group 2 were 8 men with AIDS who had mildly abnormal lung function following an episode of pneumocystis pneumonia-spirometry FEV1 3.08 (0.73) L, FVC 4.83 (0.82) L [mean (SD)]. The APE nebulizer was used to form a particulate aerosol with 200 MBq of 99mTc DTPA, which was collected in a 35 1 reservoir of air, which was subsequently inhaled. The mean (SD) inhalation time was 4.7 (0.44) min. The output of the nebulizer (% of activity inhaled) was 82%. Using planar imaging, the penetration index (right lung) in group 1 was 0.93 (0.18), mean (SD), and in group 2 it was 0.91 (0.12). There was virtually no tracheal deposition and extrapulmonary deposition (oropharynx and stomach) was less than 5% of the aerosol delivered. Single-photon emission tomography (SPET) studies carried out in five patients from group 1 confirmed homogeneous intrapulmonary deposition of 99mTc-DTPA. In view of the excellent intrapulmonary deposition of 99mTc-DTPA produced by the APE nebulizer, it may provide an alternative to conventional ventilation studies using radioactive gases.
我们报告了一种新型输送系统——气溶胶生成设备（简称为APE）的验证情况，该设备可产生质量中值空气动力学直径为0.35微米、几何标准差为1.8的锝99m二乙三胺五乙酸（DTPA）颗粒气溶胶。对20名受试者进行了研究；第1组为12名肺活量测定正常的健康男性；第2组为8名艾滋病男性患者，他们在卡氏肺孢子虫肺炎发作后肺功能轻度异常——肺活量测定第1秒用力呼气量（FEV1）为3.08（0.73）升，用力肺活量（FVC）为4.83（0.82）升[均值（标准差）]。使用APE雾化器用200MBq的99mTc DTPA形成颗粒气溶胶，该气溶胶收集在35升的空气储器中，随后被吸入。平均（标准差）吸入时间为4.7（0.44）分钟。雾化器的输出（吸入活性的百分比）为82%。使用平面成像，第1组的渗透指数（右肺）为0.93（0.18），均值（标准差），第2组为0.91（0.12）。几乎没有气管沉积，肺外沉积（口咽和胃）小于输送气溶胶的5%。对第1组的5名患者进行的单光子发射断层扫描（SPET）研究证实了99mTc-DTPA在肺内的均匀沉积。鉴于APE雾化器产生的99mTc-DTPA在肺内的出色沉积，它可能为使用放射性气体的传统通气研究提供一种替代方法。
