Baulieu E E
Ann Biol Clin (Paris). 1976;34(5):341-9.
The definition and main characteristics of the steroid hormone receptors are given. One may note a relationship between hormonal receptivity and the physiological changes in the concentration of the receptors in the target organs. The distribution of the various receptors is given in detail showing the existence of (a) different receptors for the same hormone in different target cells; (b) different receptors for different hormones in the same cells; (c) different receptors for the same hormone in the same cell. A new pharmacological approach is proposed based on differentiation of receptivities from which there results a dissociation of the therapeutic effects.
给出了类固醇激素受体的定义和主要特征。人们可能会注意到激素敏感性与靶器官中受体浓度的生理变化之间的关系。详细给出了各种受体的分布情况，显示出：(a) 同一激素在不同靶细胞中有不同受体；(b) 同一细胞中不同激素有不同受体；(c) 同一细胞中同一激素有不同受体。基于敏感性的差异提出了一种新的药理学方法，由此产生治疗效果的分离。
