Jänne O A, Kontula K K
Ann Clin Res. 1980 Oct;12(5):174-91.
The present article deals with some basic principles in the mechanism of hormone action. All classes of hormones elicit the majority of their physiological effects via specific receptors which are located in three separate compartments of target cells: cell membranes (peptide and glycopeptide hormones), cytoplasm (steroid hormones) and nucleus (thyroid and steroid hormones). These receptors, although distinctively different in their subcellular localizations share some mutual chemical characteristics which play important roles in the regulation of hormone action. Target cell receptor concentration seems to be one variable by which the magnitude and duration of hormone action is regulated, and is subject to both homologous and heterologous hormonal control. In addition, ligand-receptor interaction and occupancy of the receptors by their respective hormones are important factors that are responsible for regulation of hormone action. A major step towards understanding the physiological role of hormone receptors in man are findings that altered receptor function is involved in pathogenesis of and therapeutic approaches to a variety of diseases.
本文论述了激素作用机制中的一些基本原理。所有种类的激素都是通过位于靶细胞三个不同区室的特异性受体引发其大部分生理效应的：细胞膜（肽类和糖肽类激素）、细胞质（类固醇激素）和细胞核（甲状腺激素和类固醇激素）。这些受体虽然在亚细胞定位上明显不同，但具有一些共同的化学特性，这些特性在激素作用的调节中发挥着重要作用。靶细胞受体浓度似乎是调节激素作用强度和持续时间的一个变量，并且受到同源和异源激素的控制。此外，配体 - 受体相互作用以及各自激素对受体的占据是负责调节激素作用的重要因素。在理解激素受体在人类生理作用方面迈出的重要一步是发现受体功能改变涉及多种疾病的发病机制和治疗方法。
