Cohen D, Bale P M, Painter D M
An Esp Pediatr. 1976 Dec;9(9):69-72.
Of 109 teratomas in children 86 were benign and 23 malignant. Sacro-coccygeal and pelvic teratomas predominated 52 cases, and these fell into three groups, post-sacral, dumb bell and pre-sacral. The 34 purely posterior tumours were always congenital and benign whilst the incidence of malignancy in dum bell and pre-sacral teratomas increased as the tumour became more internal. Other sites affected in order of frequency were: the gonads, head and neck, retroperitoneal anterior mediastinum and the central nervous system. Malignant teratomas were carcinomas usually containing glandular, capillary and clear cell areas, and metastases were similar. Immature tissues in benign teratomas were usually neural or connective tissue. They did not give rise to neuroblastomas or sarcomas and did not indicate a worse prognosis. Only two originally benign teratomas later developed malignancy.
在109例儿童畸胎瘤中，86例为良性，23例为恶性。骶尾部和盆腔畸胎瘤占主导，共52例，可分为三组：骶后型、哑铃型和骶前型。34例单纯位于后方的肿瘤均为先天性且良性，而哑铃型和骶前型畸胎瘤的恶性发生率随着肿瘤向内部发展而增加。其他受累部位按频率依次为：性腺、头颈部、腹膜后、前纵隔和中枢神经系统。恶性畸胎瘤通常为癌，包含腺性、毛细血管性和透明细胞区域，并伴有相似的转移。良性畸胎瘤中的未成熟组织通常为神经或结缔组织。它们不会引发神经母细胞瘤或肉瘤，也不提示预后较差。仅有两例原本良性的畸胎瘤后来发生了恶变。
