The role of the gastric reservoir in ventilator-associated pneumonia.

Ventilator-associated pneumonia (VAP) is a common complication of mechanical ventilation with an incidence ranging from 9-70% and averaging around 25%. The pathogenesis of VAP requires abnormal oropharyngeal and gastric colonisation and then aspiration of these contents into the lower airways. Another co-existing mechanism could be direct oropharyngeal or lower airways inoculation of microorganisms through contaminated respiratory therapy equipment. Ventilator-associated pneumonia develops easily if aspiration or inoculation of microorganisms occur in patients with artificial airways and in whom mechanical, cellular and/or humoral defences are altered. Both host factors and treatments may alter pulmonary defence mechanisms; these too may contribute to the development of VAP. An alternative mechanism to explain VAP is bacterial translocation, although this mechanism is still under investigation. Figure 1 illustrates a schema of the pathogenesis of VAP. In this paper we review the possible role of the gastric reservoir in the aetiology of VAP, emphasising the following issues: 1. Risk factors for gastric colonisation 2. Clinical evidence of gastric aspiration to the lower airways in mechanically ventilated patients 3. Clinical evidence and controversies surrounding the role of the gastric reservoir in ventilator-associated pneumonia 4. The role of bacterial translocation as a mechanism for the development of VAP 5. A summary of prophylactic measures.