Clayden G S, Lawson J O
Arch Dis Child. 1976 Dec;51(12):918-23. doi: 10.1136/adc.51.12.918.
The anorectal physiology of 106 children with long-standing chronic constipation, who had failed to response to a trial of medical treatment, was assessed. 10 (9%) were shown to have ultrashort-segment Hischsprung's disease, later confirmed on histology, The remainder showed evidence of hypertrophy of the internal sphicter on anorectal manometry and had a vigorous anal dilatation (to accept 4 fingers) under general anesthesia. After this, 38% were able to be weaned off all medication and most of the remainder improved. Further anal dilatation and internal sphincterotomy allowed a further 10 children to stop laxative, bringing the total to 48%.
对106例长期慢性便秘且药物治疗试验无效的儿童的肛肠生理功能进行了评估。其中10例（9%）经组织学检查确诊为超短段先天性巨结肠，其余患儿在肛肠测压时显示内括约肌肥厚，并在全身麻醉下进行了强力扩肛（可容纳4指）。此后，38%的患儿能够停用所有药物，其余大多数患儿病情有所改善。进一步的扩肛和内括约肌切开术使另外10名患儿停止使用泻药，总计达48%。
