对100名重度持续性高血压患儿的分析。
Analysis of 100 children with severe and persistent hypertension.
作者信息
Gill D G, Mendes de Costa B, Cameron J S, Joseph M C, Ogg C S, Chantler C
出版信息
Arch Dis Child. 1976 Dec;51(12):951-6. doi: 10.1136/adc.51.12.951.
Abstract
In 100 children with persistent hypertension seen over the past 5 1/2 years the commonest causes of hypertension were chronic glomerulonephritis, reflux nephropathy, coarctation of the aorta, and obstructive uropathy, accounting for some 70% of cases. 17 children have died, but in the remainder hypertension has been controlled by surgery, chronic haemodialysis, or by the use of pharmacological agents. Methyldopa was the commonest drug used, and the children appeared relatively resistant to the side effects of this and of other drugs, even when large doses were used. The improvment is the prognosis of severe hypertension in childhood indicated in this survey is largely due to the availability of chronic haemodialysis and transplantation for end-stage renal disease, but the advances in diagnositc methods and surgical techniques and the introduction of new drugs have also contributed.
摘要
在过去5年半中所见到的100例持续性高血压患儿中，高血压最常见的病因是慢性肾小球肾炎、反流性肾病、主动脉缩窄和梗阻性尿路病，约占病例的70%。17名患儿已经死亡，但其余患儿的高血压已通过手术、慢性血液透析或使用药物得到控制。甲基多巴是最常用的药物，这些患儿对该药及其他药物的副作用表现出相对耐药，即使使用大剂量时也是如此。本次调查表明，儿童重度高血压预后的改善很大程度上归因于终末期肾病慢性血液透析和移植的可行性，但诊断方法和手术技术的进步以及新药的引入也起到了作用。
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