Hallenbeck G A, Gleysteen J J, Aldrete J S, Slaughter R L
Ann Surg. 1976 Oct;184(4):435-42. doi: 10.1097/00000658-197610000-00006.
PGV performed in 39 patients by separating the lesser omentum from the stomach beginning 6 or 7 cm proximal to the pylorus and skeletonizing the distal 1 to 2 cm of esophagus was followed by 15.4% of proven and 10.2 of suspected recurrent ulcers. Insulin tests were done during the first 3 months postoperatively on 31 of the patients, including the 6 with proven and the 4 with suspected recurrent ulcers. The peak acid output to insulin minus tha basal acid output (PAOI-BAO) was less than 5 mEq/hr in 16 cases (52%) and from 5 to 25 mEq/hr in the remaining 15 cases. In 6 patients with proven recurrent ulcer, PAOI-BAO averaged 21.9 mEq/hr (range, 11.3 to 41.8); in the 4 patients with suspected recurrence, 9.5 (range, 4.4 to 11.8). The operative technique was changed in one respect; the distal 5 to 7.5 cm of the esophagus was skeletonized. In 14 patients, the mean PAOI-BAO +/- S.E. within 3 months of PGV was 1985 +/- 0.7 mEq/hr, and 13 of 14 values were less than 5 mEq/hr. One patient developed recurrent ulcer and required re-operation; this patient's value for PAO-BAO was 1.8 mEq/hr. The results show quantitatively that great differences in the completeness of PGV result from differences in the periesophageal dissection and emphasize its importance if optimal results are to be obtained and, especially, if the efficacy of the operation is to be judged.
对39例患者进行了近端胃迷走神经切断术(PGV),从幽门近端6或7厘米处开始将小网膜与胃分离,并将食管远端1至2厘米骨骼化,术后有15.4%的患者证实复发溃疡,10.2%的患者疑似复发溃疡。对31例患者在术后前3个月进行了胰岛素试验,其中包括6例证实复发溃疡和4例疑似复发溃疡的患者。胰岛素刺激后的最大胃酸分泌量减去基础胃酸分泌量(PAOI-BAO),16例患者(52%)低于5毫当量/小时,其余15例患者在5至25毫当量/小时之间。6例证实复发溃疡的患者,PAOI-BAO平均为21.9毫当量/小时(范围为11.3至41.8);4例疑似复发的患者,为9.5毫当量/小时(范围为4.4至11.8)。手术技术在一个方面进行了改变;将食管远端5至7.5厘米骨骼化。14例患者在PGV术后3个月内的平均PAOI-BAO±标准误为19.85±0.7毫当量/小时,14个值中有13个低于5毫当量/小时。1例患者出现复发溃疡并需要再次手术;该患者的PAO-BAO值为1.8毫当量/小时。结果定量显示,PGV完整性的巨大差异源于食管周围解剖的差异,并强调如果要获得最佳结果,尤其是要判断手术疗效,食管周围解剖的重要性。