Amadori G, Semenzato G, Tosato F, Cazzaro G, Sarasin P, Gasparotto G
Boll Ist Sieroter Milan. 1976;55(5):426-30.
In 22 cases of myeloma and 12 cases of benign paraproteinemia the functional situation of circulating lymphocytes was studied. The technique used was the incorporation of 3H-Thymidine after PHA stimulation. E rosette formation and immunoglobulin bearing cells were evaluated. A reduction of 3H-Thymidine incorporation in the blastic cells was seen in the patients with myeloma (2,942 +/- 421 cpm/10(6) lymphocytes in respect to 13,182 +/- 920 of the control group). The difference was statistically significant: p less than 0.001. In benign monoclonal gammopathies the reduction was moderate and was at the limits of the significance: 9,482 +/- 1,100. The percentage of E rosettes and of immunoglobulins bearing cells was normal. The different behaviour of the blastic response in vitro in the two groups of patients tested confirms that the respective condition of the immunocompetent system is clearly different. A possible interpretation of this type of behaviour is discussed.
对22例骨髓瘤患者和12例良性副蛋白血症患者的循环淋巴细胞功能状况进行了研究。采用的技术是在PHA刺激后掺入3H-胸腺嘧啶核苷。评估了E玫瑰花结形成和携带免疫球蛋白的细胞。骨髓瘤患者的母细胞中3H-胸腺嘧啶核苷掺入量减少（相对于对照组的13,182 +/- 920，为2,942 +/- 421 cpm/10(6)淋巴细胞）。差异具有统计学意义：p < 0.001。在良性单克隆丙种球蛋白病中，减少程度适中且处于显著意义的界限：9,482 +/- 1,100。E玫瑰花结和携带免疫球蛋白细胞的百分比正常。在两组受试患者中体外母细胞反应的不同表现证实，免疫活性系统的各自状况明显不同。讨论了这种行为类型的一种可能解释。
