Jahn S, Bürger W, Kiessig S T, Volk H D, Grunow R, von Baehr R
Allerg Immunol (Leipz). 1986;32(3):185-91.
The influence of C-reactive protein (CRP) on early and late parameters of mitogen-induced lymphocyte activation in vitro has been tested. Early activation markers (increase of cell size and formation of thermostable SE rosettes) and the lymphocyte proliferation (3H-thymidine incorporation) were changed by CRP (10-50 micrograms/ml), whereas PWM-induced stimulation was inhibited and PHA-induced activation was enhanced. Production of human immunoglobulins in vitro in culture from 12 healthy donors was influenced by CRP in a different manner. Modulation of mitogenic responses of lymphocytes by CRP occurs in an early stage of the cell cycle. Responsible for this phenomenon can be soluble factors, which were removed from the culture by washing the cells after 24 hrs. We discuss here the unspecific modulatory role of CRP in various immune-mediated diseases.
已对C反应蛋白（CRP）在体外对丝裂原诱导的淋巴细胞活化的早期和晚期参数的影响进行了测试。CRP（10 - 50微克/毫升）改变了早期活化标志物（细胞大小增加和热稳定SE花环形成）以及淋巴细胞增殖（3H - 胸苷掺入），而PWM诱导的刺激受到抑制，PHA诱导的活化增强。来自12名健康供体的体外培养物中人类免疫球蛋白的产生受到CRP的不同影响。CRP对淋巴细胞有丝分裂反应的调节发生在细胞周期的早期阶段。对此现象负责的可能是可溶性因子，在24小时后通过洗涤细胞将其从培养物中去除。我们在此讨论CRP在各种免疫介导疾病中的非特异性调节作用。
