Hamilton C L, Ciaccia P
J Med Primatol. 1978;7(3):165-73. doi: 10.1159/000459806.
Longitudinal studies of the rhesus monkey reveal a syndrome of diabetes mellitus in those that become middle-aged and obese. The sequence of events in the development of the disease progresses from normoinsulinemia with normoglycemia through stages of hyperinsulinemia followed by below normal insulin levels with hyperglycemia and glycosuria. We believe the rhesus to be an excellent nonhuman primate model for maturity-onset diabetes in humans.
对恒河猴的纵向研究揭示了那些步入中年且肥胖的猴子会出现糖尿病综合征。该疾病发展过程中的一系列事件从正常胰岛素血症伴正常血糖开始，历经高胰岛素血症阶段，随后胰岛素水平低于正常并伴有高血糖和糖尿。我们认为恒河猴是人类成年型糖尿病的优良非人灵长类动物模型。
