Hannah J S, Verdery R B, Bodkin N L, Hansen B C, Le N A, Howard B V
Department of Physiology, School of Medicine, University of Maryland, Baltimore 21201.
J Clin Endocrinol Metab. 1991 May;72(5):1067-72. doi: 10.1210/jcem-72-5-1067.
Abnormalities in plasma lipoprotein concentrations commonly found in subjects with noninsulin-dependent diabetes may be related to insulin resistance, hyperinsulinemia, hyperglycemia, or other metabolic defects. The middle-aged obese rhesus monkey is an animal model in which these defects can be separated in time during the development of diabetes. It is, therefore, a model system for examining the sequence of metabolic changes which occur before and after the onset of diabetes. This sequence of changes was used in the present study to determine if lipoprotein changes occur in association with the development of diabetes in the rhesus monkey. Increases in plasma triglyceride, very low density lipoprotein (VLDL) triglyceride, and VLDL cholesterol, and decreases in high density lipoprotein cholesterol were observed across previously identified groups ranging from normal to diabetic. Plasma triglycerides increased from 0.54 +/- 0.09 (normal) to 1.27 +/- 0.50, 1.93 +/- 0.79, and 4.28 +/- 2.24 in three intermediate groups with progressive hyperinsulinemia and insulin resistance, to 7.59 +/- 2.73 mmol/L in the diabetic monkeys. Increases in VLDL triglyceride and VLDL cholesterol paralleled the plasma triglyceride increases. High density lipoprotein cholesterol decreased across the groups from 2.33 +/- 0.16 (normal) to 1.72 +/- 0.20, 1.17 +/- 0.13, and 1.09 +/- 0.20 mmol/L in the intermediate groups, and was lowest in the diabetic monkeys, 1.00 +/- 0.21. The obese rhesus monkey can therefore be used to study lipoprotein abnormalities as they occur both before and in noninsulin-dependent diabetes.
非胰岛素依赖型糖尿病患者中常见的血浆脂蛋白浓度异常可能与胰岛素抵抗、高胰岛素血症、高血糖或其他代谢缺陷有关。中年肥胖恒河猴是一种动物模型，在糖尿病发展过程中，这些缺陷可在时间上被区分开来。因此，它是一个用于研究糖尿病发病前后发生的代谢变化顺序的模型系统。本研究利用这一变化顺序来确定恒河猴糖尿病发展过程中脂蛋白变化是否与之相关。在先前确定的从正常到糖尿病的各组中，观察到血浆甘油三酯、极低密度脂蛋白（VLDL）甘油三酯和VLDL胆固醇升高，高密度脂蛋白胆固醇降低。血浆甘油三酯从0.54±0.09（正常）升高到三个胰岛素血症和胰岛素抵抗逐渐加重的中间组中的1.27±0.50、1.93±0.79和4.28±2.24，在糖尿病猴中升高到7.59±2.73 mmol/L。VLDL甘油三酯和VLDL胆固醇的升高与血浆甘油三酯的升高平行。各组中高密度脂蛋白胆固醇从2.33±0.16（正常）降至中间组中的1.72±0.20、1.17±0.13和1.09±0.20 mmol/L，在糖尿病猴中最低，为1.00±0.21。因此，肥胖恒河猴可用于研究非胰岛素依赖型糖尿病发病前及发病时出现的脂蛋白异常。
