Novikov N M, Blium L I, Stagis A V
Biull Eksp Biol Med. 1976;82(11):1311-3.
The degree of hemolysis was studied comparatively in intact and nephrectomized rats after the phenylhydrazine injection. In the nephrectomized animals hemolytic (phenylhydrazine) anemia was expressed by a lesser reduction of the total erythrocyte count, of the percentage of Cr51-labeled erythrocytes, and of the intensity of the reaction for hemosiderin in the organs and tissues. A lesser degree of erythrodieresis was found in the nephrectomized rats and after an acute unsubstituted blood loss. Blood perfusion through the kidney of anemic rats led to increase of the potassium concentration in the plasma perfusate, reduction of the electrophoretic mobility of erythrocytes, their resistance, hemolysis duration, and to decrease of albumin fractions with the mol wt of from 74 500 to 27 000 in the erythrocyte stroma.
在注射苯肼后，对完整大鼠和肾切除大鼠的溶血程度进行了比较研究。在肾切除的动物中，溶血性（苯肼所致）贫血表现为全红细胞计数、Cr51标记红细胞百分比以及器官和组织中铁蛋白反应强度的降低程度较小。在肾切除大鼠和急性单纯性失血后，发现红细胞分裂程度较低。贫血大鼠肾脏的血液灌注导致血浆灌注液中钾浓度升高、红细胞电泳迁移率降低、红细胞抵抗力和溶血持续时间增加，并导致红细胞基质中分子量从74500至27000的白蛋白组分减少。
