[Dynamics of thyroid hormone content in blood serum in phenylhydrazine-induced and acute posthemorrhagic anemias].

Hormonal changes were studied in hemopoietic disorders. Phenylhydrazine-induced and acute posthemorrhagic anemias were simulated in male Wistar rats. Radioimmunoassay was used to determine the serum levels of thyroid hormones (thyroxine and triiodothyronine) 2, 6, 12, and 24 hours after erythropoietic stress. There was a time course of changes in the levels of thyroid hormones. Administration of a hemolytic poison caused heterodirectional changes in the concentrations of thyroid hormones: an increase of triiodothyronine and a decrease in thyroxine with their normalization at hour 24. Acute blood letting resulted in a significant reduction in the levels both of triiodothyronine and thyroxine in the first hours after exposure. The same time course in the changes in thyroxine levels was observed in test and control groups.