Iaroshevskiĭ Iu A
Biull Eksp Biol Med. 1976;82(11):1322-4.
A study was made of insulin sensitivity of the adipose tissue biopsied in 11 healthy women, and in 10 women with normal weight suffering from newly-detected diabetes mellitus. In difference from healthy persons in the adipose tissue of patients suffering from diabetes, insulin in a concentration of 50 mu/ml failed to enhance the oxidation of glucose to CO2, and in a concentration of 50 and 100 mu/ml failed to enhance the glycogen synthesis from glucose. Reduction of the sensitivity of different ways of glucose metabolism in the adipose tissue to insulin in patients suffering from diabetes mellitus pointed to the possibility of disturbance of insulin interaction with the cell membrane in this disease.
对11名健康女性以及10名体重正常的新诊断糖尿病女性的脂肪组织活检样本进行了胰岛素敏感性研究。与健康人不同，糖尿病患者脂肪组织中，50微单位/毫升浓度的胰岛素未能增强葡萄糖氧化为二氧化碳的过程，50和100微单位/毫升浓度的胰岛素也未能增强由葡萄糖合成糖原的过程。糖尿病患者脂肪组织中不同葡萄糖代谢方式对胰岛素的敏感性降低，表明该病可能存在胰岛素与细胞膜相互作用的紊乱。
