Iaroshevskiĭ Iu A
Probl Endokrinol (Mosk). 1977 May-Jun;23(3):3-7.
The intensity of lipid synthesis from the C-14-labeled glucose in the isolated subcutaneous fatty tissue of healthy individuals and diabetic patients was investigated during incubation of the tissue in the serum of healthy individuals and of those suffering from diabetes mellitus. It was shown that the serum of healthy individuals and of patients with diabetes mellitus enhanced the lipid synthesis in the adipose tissue of healthy individuals (significantly and equally) in comparison with the incubation in buffer solution. But no lipid synthesis was stimulated under the effect of the serum of healthy persons and patients with diabetes mellitus in the adipose tissue of diabetic patients. The data obtained indicated that antagonists to the insulin action on adipose tissue were absent in the blood of patients with diabetes mellitus. A reduction of the adipose tissue sensitivity of diabetic patients to insulin contained in the serum was due to the tissue defect representing the primary factor in the pathogenesis of the diabetes mellitus responsible for the development of relative insulin deficiency.
在健康个体和糖尿病患者的皮下脂肪组织与健康个体血清及糖尿病患者血清共同孵育过程中，研究了从C-14标记葡萄糖合成脂质的强度。结果表明，与在缓冲溶液中孵育相比，健康个体血清和糖尿病患者血清均能（显著且同等程度地）增强健康个体脂肪组织中的脂质合成。但在健康人和糖尿病患者血清作用下，糖尿病患者脂肪组织中未刺激脂质合成。所获数据表明，糖尿病患者血液中不存在胰岛素对脂肪组织作用的拮抗剂。糖尿病患者脂肪组织对血清中胰岛素敏感性降低是由于组织缺陷，这是糖尿病发病机制中导致相对胰岛素缺乏的主要因素。
