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[小鼠肿瘤与正常组织在24小时内有丝分裂活性水平及有丝分裂持续时间的比较研究]

[Comparative study of the level of mitotic activity and duration of mitosis over a 24 hour period in mouse tumors and normal tissue].

作者信息

Berezkin M V

出版信息

Biull Eksp Biol Med. 1976;82(11):1363-5.

PMID:1016722
Abstract

Circadian rhythm of cell division in the forestomack epithelium proved to be largely similar to that in the transplantable (continuous) carcinoma of the forestomack; the duration of mitosis in these tissues changed in the course of 24-hours. The mean 24-hour mitotic activity in the tumour was double that in the forestomack contrary to this, colchamine (colcemide) accumulated in the course of the 24-hours 121.1% mitoses in the forestomack and 83.8% mitoses in the carcinoma. A greater number of mitoses in the tumour with the usual count is attributed to the fact that the mean 24-hour duration of mitosis of the remen carcinoma was 2.7 greater than in the epithelium of the forestomack.

摘要

前胃上皮细胞分裂的昼夜节律被证明与前胃可移植性(持续性)癌中的昼夜节律大体相似;这些组织中细胞分裂的持续时间在24小时内会发生变化。肿瘤中平均24小时有丝分裂活性是前胃的两倍。与此相反,秋水仙胺(秋水仙酰胺)在24小时内在前胃中积累了121.1%的有丝分裂,在癌中积累了83.8%的有丝分裂。肿瘤中通常计数的有丝分裂数量更多,这归因于瘤胃癌平均24小时有丝分裂持续时间比前胃上皮长2.7倍这一事实。

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