Grassi V, Boschetti E, Todisco T, Sorbini C A, Muiesan G
Bull Eur Physiopathol Respir. 1976 Jan-Feb;12(1):103-9.
Acid-base parameters were studied in 10 adult patients with chronic respiratory failure during spontaneous acute exacerbations of chronic hypercapnia and after return and stabilization of PaCO2 values at previous levels with improvement of clinical conditions. All factors interfering with acid-base equilibrium were carefully avoided. The results of this investigation confirm qualitatively those obtained by GOLDSTEIN et al. [7] in dog studies and those of INGRAM et al. [9]in human studies: increasing degrees of chronic hypercapnia tend to minimize the pH reduction induced by acute PACO2 changes. From a quantitative standpoint INGRAM's data in humans are considerably different from GOLDSTEIN's data obtained in dogs. Our data, although numerically limited, confirm the acute deltaH+/deltaPaCO2 slope obtained from dogs by GOLDSTEIN et al. As data are not yet sufficient, definitive conclusions cannot be drawn. However the pattern of acid-base equilibrium changes in man in this situation seems to be similar to that observed by GOLDSTEIN et al. in the dog and could be described with reasonable accuracy by the theoretical model of LEUENBERGER et al.[13].
对10例慢性呼吸衰竭成年患者在慢性高碳酸血症自发性急性加重期间以及在临床状况改善、PaCO2值恢复并稳定至先前水平后，进行了酸碱参数研究。仔细避免了所有干扰酸碱平衡的因素。本研究结果在质量上证实了GOLDSTEIN等人[7]在犬类研究中以及INGRAM等人[9]在人体研究中所获得的结果：慢性高碳酸血症程度的增加往往会使急性PACO2变化引起的pH降低最小化。从定量角度来看，INGRAM在人体中的数据与GOLDSTEIN在犬类中获得的数据有很大差异。我们的数据虽然数量有限，但证实了GOLDSTEIN等人从犬类获得的急性ΔH⁺/ΔPaCO2斜率。由于数据尚不充分，无法得出明确结论。然而，在这种情况下人类酸碱平衡变化的模式似乎与GOLDSTEIN等人在犬类中观察到的相似，并且可以用LEUENBERGER等人[13]的理论模型进行合理准确的描述。
