高碳酸血症时的脑有机酸
Brain organic acids during hypercapnia.
作者信息
Weyne J, Van Leuven F, Leusen I
出版信息
Bull Eur Physiopathol Respir. 1976 Mar-Apr;12(2):285-95.
PMID:1016784
Abstract
Experiments in rats during acute and prolonged periods of hypercapnia show important changes in the glutamate and glutamine content of the brain. Compartmentation studies using labelled glutamate intracisternally injected show an increased turnover of the small glutamate compartment. The possible pathophysiological significance of these observations is discussed.
摘要
对大鼠在急性和长期高碳酸血症期间进行的实验表明，大脑中的谷氨酸和谷氨酰胺含量发生了重要变化。使用脑池内注射标记谷氨酸进行的区室化研究表明，小谷氨酸区室的周转率增加。讨论了这些观察结果可能的病理生理学意义。
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