Van Leuven F, Weyne J, Leusen I
Arch Int Physiol Biochim. 1977 Apr;85(2):295-304. doi: 10.3109/13813457709058762.
In order to study the influence of hypercapnia on the content of glutamate and glutamine in the developing brain, pregnant rats and their offspring were kept in CO2 rich (6-10%) atmosphere and the litters were killed at different ages between 4 and 28 days. In the hypercapnic rats the content of both amino acids in the brain increases with age with almost the same time course as in normocapnic rats. At any age the glutamate content is lower in the hypercapnic animals than in control rats, whereas the glutamine content, beyond the first 8 days of life is increased. Both effects are rapidly reversible on return to air breathing. Although the glutamate-glutamine system is in full development, the influence of hypercapnia can be compared to that observed in adult rats. Hypercapnia did not change the glutaminase and the glutamine synthetase activity of the brain.
为研究高碳酸血症对发育中大脑谷氨酸和谷氨酰胺含量的影响，将怀孕大鼠及其后代置于富含二氧化碳（6 - 10%）的环境中，并在4至28天的不同年龄段处死幼崽。在高碳酸血症大鼠中，大脑中这两种氨基酸的含量随年龄增加，其时间进程与正常碳酸血症大鼠几乎相同。在任何年龄段，高碳酸血症动物的谷氨酸含量均低于对照大鼠，而谷氨酰胺含量在出生后8天之后增加。这两种效应在恢复呼吸空气后均可迅速逆转。尽管谷氨酸 - 谷氨酰胺系统已完全发育，但高碳酸血症的影响与成年大鼠中观察到的情况相似。高碳酸血症并未改变大脑的谷氨酰胺酶和谷氨酰胺合成酶活性。
