不同亚硝基化合物对中国仓鼠的致癌作用：N-二丁基亚硝胺和N-亚硝基甲基脲。
Carcinogenic effects of different nitroso-compounds in chinese hamsters: N-dibutylnitrosamine and N-nitrosomethylurea.
作者信息
Reznik G, Mohr U, Kmoch N
出版信息
Cancer Lett. 1976 Mar;1(4):183-8. doi: 10.1016/s0304-3835(75)96568-4.
PMID:1016942
Abstract
Three hundred and twenty Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s.c.) treated with 1/5, 1/10 or 1/20 the mean lethal dose (LD50) of N-dibutylnitrosamine (DBN) or N-nitrosomethylurea (NMU). In several respects these two substances produced the same organotropy in the CH as in the Syrian golden (SGH) and European hamsters (EH). DBN prolonged lung tumours and neoplasms of the injection site. NMU induced tumours of the injection site only.
摘要
用N-二丁基亚硝胺（DBN）或N-亚硝基甲基脲（NMU）平均致死剂量（LD50）的1/5、1/10或1/20对320只中国仓鼠（黑线仓鼠）进行皮下注射处理。在几个方面，这两种物质在中国仓鼠身上产生的器官亲和性与在叙利亚金仓鼠（SGH）和欧洲仓鼠（EH）身上相同。DBN使肺部肿瘤和注射部位肿瘤增多。NMU仅诱发注射部位肿瘤。
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