二甲基亚硝胺和亚硝基甲基脲对欧洲仓鼠（黑线仓鼠）的致癌作用。
The carcinogenic effects of dimethylnitrosamine and nitrosomethylurea in European hamsters (Cricetus cricetus L.).
作者信息
Mohr U, Haas H, Hilfrich J
出版信息
Br J Cancer. 1974 May;29(5):359-64. doi: 10.1038/bjc.1974.83.
Abstract
The carcinogenic effects of dimethylnitrosamine (DMN) and nitrosomethylurea (NMU) injected subcutaneously at 3 different dose levels in European hamsters were studied. DMN induced malignant haemangioendotheliomata of the liver and kidney, hepatocellular carcinomata and, in one animal, a cholangiocellular carcinoma. The effect of NMU was localized at the site of administration and resulted in subcutaneous fibrosarcomata, carcinosarcomata or epidermal carcinomata.
摘要
研究了在欧洲仓鼠皮下注射3种不同剂量水平的二甲基亚硝胺（DMN）和亚硝基甲基脲（NMU）的致癌作用。DMN诱发了肝脏和肾脏的恶性血管内皮瘤、肝细胞癌，并且在一只动物中诱发了胆管细胞癌。NMU的作用局限于给药部位，导致皮下纤维肉瘤、癌肉瘤或表皮癌。
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