两种免疫抑制剂对光致癌作用的影响

Modification of photocarcinogenesis by two immunosuppressive agents.

作者信息

Nathanson R B, Forbes P D, Urbach F

出版信息

Cancer Lett. 1976 May;1(5):243-7. doi: 10.1016/s0304-3835(75)97305-x.

Abstract

The carcinogenic effect of ultraviolet radiation (UVR) on the skin of hairless (hr) mice was modified by two immunosuppressive agents, rabbit anti-mouse lymphocytic serum (ALS), and 6-mercaptopurine (6MP). Daily exposure of mice to UVR resulted in multiple tumor production. Carcinogenesis was measured in terms of affected mice (prevalence) and numbers of tumors produced. By both criteria, photocarcinogenesis was enhanced by ALS but inhibited by 6MP.

摘要

两种免疫抑制剂，即兔抗小鼠淋巴细胞血清（ALS）和6-巯基嘌呤（6MP），改变了紫外线辐射（UVR）对无毛（hr）小鼠皮肤的致癌作用。每天让小鼠暴露于UVR会导致多发性肿瘤产生。根据受影响的小鼠数量（发生率）和产生的肿瘤数量来衡量致癌作用。按照这两个标准，ALS增强了光致癌作用，而6MP则抑制了光致癌作用。