Therin M, Christel P, Crespeau F, Dürselen L, Claes L
Service de Chirurgie Orthopédique et Traumatologique, Hôpital Saint-Louis, Paris, France.
Clin Mater. 1994;15(1):69-75. doi: 10.1016/0267-6605(94)90011-6.
In order to evaluate the potential use of polyarylamide fibers as a prosthetic material for ligament replacement, resected sheep anterior cruciate ligaments were replaced by braided devices routed through a tibial tunnel and over the top of the lateral femoral condyle. Twelve sheep were used and sacrificed between 3 and 12 months. The tissue response to the implant was evaluated histologically. Morphologic features of the fibers and the abraded particles were measured by image analysis. Simultaneously, the tensile properties as well as the creep and fatigue properties of non-implanted prostheses were measured under laboratory conditions. It was shown that the polyarylamide fibers exhibited high strength, a high modulus, but low fatigue abrasion properties. At autopsy, 1 prosthesis was broken, 6 had frayed and 5 were intact. There was no adverse tissue response to the intact fibers. Inflammation was always linked to the presence of polymeric particles. A large bony ingrowth in the tibial tunnel through the prostheses strands was observed. There was no material resorption throughout the experiment. Polyarylamide fibers appear to be a suitable material for ligament replacement provided that abrasion against bone can be avoided.
为了评估聚芳酰胺纤维作为韧带替代假体材料的潜在用途，将切除的绵羊前交叉韧带用编织装置替代，该装置穿过胫骨隧道并置于股骨外侧髁上方。使用了12只绵羊，并在3至12个月之间进行了处死。通过组织学评估对植入物的组织反应。通过图像分析测量纤维和磨损颗粒的形态特征。同时，在实验室条件下测量未植入假体的拉伸性能以及蠕变和疲劳性能。结果表明，聚芳酰胺纤维具有高强度、高模量，但疲劳磨损性能较低。尸检时，1个假体断裂，6个磨损，5个完好无损。对完好的纤维没有不良组织反应。炎症总是与聚合物颗粒的存在有关。观察到通过假体束在胫骨隧道中有大量骨向内生长。在整个实验过程中没有材料吸收现象。只要能避免与骨的磨损，聚芳酰胺纤维似乎是一种适合韧带替代的材料。
