Amis A A
Mechanical Engineering Department, Imperial College, London, UK.
Clin Mater. 1994;15(1):51-60. doi: 10.1016/0267-6605(94)90009-4.
This paper describes the work done in developing the Apex polyester fibre cruciate ligament implant. A series of animal experiments showed that the material was the basis for good collagenous tissue ingrowth at the calcaneal tendon and within the knee joint. The rate of increase of strength of ingrowth at the calcaneal tendon was investigated. The slow maturation led to the development of a stainless steel screw and grommet anchorage system, which was also tested in vitro. A long-term animal study of the clinical implant and anchor system showed the implant fibres spaced apart by prolific ingrowth, while no implant particles were found, and there was no evidence of synovitis. The tissue reactions in human use have been found to be the same as in the animals, while ultrastructural study of retrieved specimens has given evidence of long-term collagen maturation.
本文描述了在开发Apex聚酯纤维交叉韧带植入物方面所做的工作。一系列动物实验表明，该材料是跟腱和膝关节内良好的胶原组织向内生长的基础。研究了跟腱处向内生长强度的增加速率。由于成熟缓慢，开发了一种不锈钢螺钉和索环锚固系统，并在体外进行了测试。对临床植入物和锚固系统的长期动物研究表明，植入纤维因大量向内生长而间隔开，未发现植入颗粒，也没有滑膜炎的证据。已发现该植入物在人体使用中的组织反应与在动物中相同，而对回收标本的超微结构研究提供了长期胶原成熟的证据。
