Andreopoulos A G
Department of Chemical Engineering, National Technical University of Athens, Zografos, Greece.
Clin Mater. 1994;15(2):89-92. doi: 10.1016/0267-6605(94)90074-4.
The design of a plasticized, biodegradable polymeric material, suitable for application as a controlled-release system, was attempted. A poly(DL-lactic acid) oligomer was plasticized with 1,2-propylene glycol and glycerol. The latter plasticizer showed poor compatibility whereas 1,2-propylene glycol was compatible with the polymer up to high concentrations. The mixtures prepared displayed considerable depression of processing temperature and enhanced delivery of salicylic acid, in the early stages of release. It seemed, therefore, feasible to produce systems which allow easy and safe processing and can be injected into a body cavity, without the need for surgical retrieval after completion of the release. Furthermore, the differential rate of drug delivery might be of profound interest for cases where elevated drug doses are necessary in the beginning of treatment.
尝试设计一种适用于控释系统的增塑可生物降解聚合物材料。用1,2 - 丙二醇和甘油对聚（DL - 乳酸）低聚物进行增塑。后一种增塑剂显示出较差的相容性，而1,2 - 丙二醇在高浓度下仍与聚合物相容。所制备的混合物在加工温度上有显著降低，并且在释放初期水杨酸的释放量增加。因此，生产出易于安全加工且可注入体腔、释放完成后无需手术取出的系统似乎是可行的。此外，对于治疗开始时需要高剂量药物的情况，药物递送的差异速率可能具有深远意义。
