[Effect of intravenous infusions of thrombin and heterogenous blood on lymph coagulability].

In dogs, i.v. administration of thrombin leads to hypocoagulation, consumption of fibrinogen, increasing fibrinolysis, and to a slight raise of antithrombin. This has no connection with appearance of natural anticoagulants and fibrinolytic agents in the lymph stream. After the heterotransfusion shock, apart from hypocoagulation and hyperfibrinolysis in the blood, the incoagulability of lymph developes due to a sharp increase of free heparin in it. The hypocoagulation after the heterotransfusion shock seems to depend on appearance of anticoagulants in the tissue fluid and lymph. Common and different features of thrombin and heterogenic blood effects on the mechanism of hypocoagulation and hyperfibrinolysis, are discussed.