[Mechanism of development of secondary hypocoagulation in frogs following intravenous thrombin administration].

Appearing of thrombin in vessels leads to formation of fibrin clots followed by consumption of clotting factors and developing of repeated hypocoagulation. In dissolution of fibrin the important role belongs to fibrinolysis, leucocytes, and reticuloendothelium. I. v. administration of thrombin in frogs with destroyed spinal cord caused intravascular clotting with following readjustment of blood flow. Dissolution of the clots in vagotomized frogs occurred more slowly than in intact frogs.