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大鼠抗右旋糖酐和抗卵清蛋白反应性的被动转移研究。

Studies on passive transfer of anti-dextran and anti-egg albumin reactivity in the rat.

作者信息

Baxter J H, Adamik R

出版信息

Int Arch Allergy Appl Immunol. 1976;52(1-4):196-204. doi: 10.1159/000231682.

DOI:10.1159/000231682
PMID:1017890
Abstract

We were unable, passively, to transfer reactivity against dextran to the skin or peritoneal mast cells of non-dextran-reactive rats, by using serum or material eluted at pH 3 from mast cells of spontaneously dextran-reactive rats. When the dextran-reactive donor rats had also been immunized against egg albumin (EA) with pertussis vaccine (inducing IgE anti-EA antibody), passive sensitivity against EA (but not against dextran) could easily be transferred. The results indicated that the anti-dextran reactivity is not due to IgE antibody. Systemic reactions against dextran and EA differed in pattern, supporting the concept that the two substances acted through different mechanisms.

摘要

我们无法通过使用自发对葡聚糖有反应的大鼠肥大细胞在pH 3条件下洗脱的血清或物质,将针对葡聚糖的反应性被动转移至非葡聚糖反应性大鼠的皮肤或腹膜肥大细胞。当对葡聚糖有反应的供体大鼠也用百日咳疫苗免疫了卵清蛋白(EA)(诱导IgE抗EA抗体)时,针对EA(而非葡聚糖)的被动敏感性很容易被转移。结果表明,抗葡聚糖反应性并非由IgE抗体引起。针对葡聚糖和EA的全身反应模式不同,支持了这两种物质通过不同机制起作用的概念。

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