Melamed R, Aygen M M, Lowenstein A
Isr J Med Sci. 1976 Nov;12(11):1325-8.
A further case of osteogenesis imperfecta with valvular heart disease is added to the 12 already reported in the literature. The presence of a dilated mitral annulus and a ballooned mitral leaflet in this case together with the findings reported in the literature leave little doubt as to the relationship between the valvular lesion and the underlying connective tissue disorder.
文献中已报道了12例成骨不全合并瓣膜性心脏病的病例，本文又增加了1例。该病例中二尖瓣环扩张和二尖瓣叶气球样变，再加上文献中报道的研究结果，使得瓣膜病变与潜在结缔组织疾病之间的关系几乎毋庸置疑。
