Harrison H N, Gutterman B, Haynie M, Weintraub H, Brandt B
Lab Anim Sci. 1976 Dec;26(6 Pt 1):917-21.
As a preliminary to a membrane oxygenator study, a study was made of clotting indices in dogs and their intercorrelation and relationship to human data. The most useful criterion for monitoring coagulation in experimental extracorporeal systems was sought. Linear regression and correlation analysis indicated that activated partial thromboplastin time (APTT) predicted whole blood clotting time with a correlation of 0.77 (p less than 0.01). Changes in the APTT with time after heparinization were similar to those previously reported in man, making the animal model an acceptable one for use in developing extracorporeal systems such as the membrane oxygenator. When blood activated recalcification time (BART), APTT, and whole blood clotting time (WBCT) assays were compared on the basis of applicability to studies of extracorporeal support, the APTT and the BART assays proved superior to the WBCT assay due to their reduced variability and increased speed of determination. The variability of the BART assay was the lowest, and its sensitivity was the same as the APTT assay. The principal drawback to the BART assay was not experienced in this study; that is, its dependence on adequate platelet levels which are unpredictable in extracorporeal systems.
作为膜式氧合器研究的前期工作，对狗的凝血指标及其相互关系以及与人类数据的关系进行了研究。旨在寻找实验体外循环系统中监测凝血的最有用标准。线性回归和相关性分析表明，活化部分凝血活酶时间（APTT）预测全血凝血时间的相关性为0.77（p小于0.01）。肝素化后APTT随时间的变化与先前在人类中报道的相似，这使得该动物模型可用于开发如膜式氧合器等体外循环系统。当基于对体外循环支持研究的适用性比较血液活化复钙时间（BART）、APTT和全血凝血时间（WBCT）检测时，由于其变异性降低和测定速度加快，APTT和BART检测被证明优于WBCT检测。BART检测的变异性最低，其灵敏度与APTT检测相同。本研究未遇到BART检测的主要缺点，即它依赖于体外循环系统中不可预测的足够血小板水平。
