遗传性尿崩症大鼠下丘脑微切割区域的血管加压素和催产素含量
Vasopressin and oxytocin content of microdissected hypothalamic areas in rats with hereditary diabetes insipidus.
作者信息
George J M, Forrest J
出版信息
Neuroendocrinology. 1976;21(3):275-9. doi: 10.1159/000122533.
PMID:1018733
Abstract
Vasopressin was virtually absent from 5 microdissected hypothalamic areas and from the posterior pituitary glands of homozygous Brattleboro rats. The oxytocin concentration was normal in all these areas except for the arcuate nucleus, where it was absent. These results support the concept that Brattleboro rats have a specific defect in biosynthesis of vasopressin. The significance of the absence of oxytocin from the arcuate nucleus in these rats remains to be determined.
摘要
在5个显微解剖的下丘脑区域以及纯合布拉特洛伯大鼠的垂体后叶中，血管加压素几乎不存在。除了弓状核中催产素浓度缺失外，所有这些区域的催产素浓度均正常。这些结果支持了布拉特洛伯大鼠在血管加压素生物合成方面存在特定缺陷的观点。这些大鼠弓状核中缺乏催产素的意义仍有待确定。
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