Szabo S T, de Montigny C, Blier P
Neurobiological Psychiatry Unit, McGill University, Montreal, Canada.
Br J Pharmacol. 1999 Feb;126(3):568-71. doi: 10.1038/sj.bjp.0702343.
Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous firing activity of locus coeruleus noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing activity. Thus, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction of the firing rate of noradrenergic neurons. The SSRI paroxetine therefore alters the activity of noradrenergic neurons with a delay that is consistent with its therapeutic action in depression and panic disorder.
利用体内细胞外单位记录法，研究了选择性5-羟色胺再摄取抑制剂（SSRI）帕罗西汀（10毫克/千克/天，皮下注射，使用渗透微型泵）短期（2天）和长期（21天）给药对蓝斑去甲肾上腺素能神经元自发放电活动的影响。长期而非短期治疗显著降低了放电活动。因此，似乎持续给予SSRI增强5-羟色胺神经传递会导致去甲肾上腺素能神经元放电率降低。SSRI帕罗西汀因此会延迟改变去甲肾上腺素能神经元的活动，这与其在抑郁症和恐慌症中的治疗作用相一致。
