Salman H, Bergman M, Bessler H, Alexandrova S, Djaldetti M
Department of Medicine C, Rabin Medical Center, Petah Tiqva, Israel.
Cancer. 1999 Mar 15;85(6):1375-9.
Cardiotoxicity, including ischemia and myocardial infarction, is one of the complications observed after treatment with interferon (IFN). Therefore, the question has been raised whether IFN may cause damage to the small myocardial blood vessels.
In this study, 400 U of IFN-alpha-2b per g of body weight were injected intraperitoneally into 2 groups of C57 B1 mice, 5 days a week for 3 and 5 months, respectively. Thin sections of the myocardium were examined with a transmission electron microscope and the ultrastructure of the capillaries was compared with that of control animals.
The results showed a statistically significant increase in the thickness of the endothelial processes of the myocardial capillary walls in the mice treated with IFN, with a subsequent decrease in the size of the capillary lumen. The entire capillary area was not affected.
These findings may serve as an additional explanation for the cardiac complications observed in patients treated with IFN.
心脏毒性，包括局部缺血和心肌梗死，是干扰素（IFN）治疗后观察到的并发症之一。因此，有人提出干扰素是否可能损害心肌小血管的问题。
在本研究中，将每克体重400单位的α-2b干扰素腹腔注射到2组C57 B1小鼠中，分别每周5天，持续3个月和5个月。用透射电子显微镜检查心肌薄片，并将毛细血管的超微结构与对照动物的进行比较。
结果显示，接受干扰素治疗的小鼠心肌毛细血管壁内皮突起厚度有统计学意义的增加，随后毛细血管腔大小减小。整个毛细血管面积未受影响。
这些发现可能为接受干扰素治疗的患者中观察到的心脏并发症提供额外的解释。
