Wong K T, Shamsol S
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
J Cutan Pathol. 1999 Jan;26(1):13-6. doi: 10.1111/j.1600-0560.1999.tb01784.x.
The association of mast cells with typical lesions of Kimura's disease was investigated by quantitative methods after immunohistochemical staining for Factor VIII-related antigen and counterstaining with toluidine blue. Formalin-fixed, paraffin-embedded, tissue sections from 9 confirmed cases of Kimura's disease were examined after staining to estimate mast cell and blood vessel densities by counting 100 random fields under oil immersion. There was a statistically significant increase of both mast cells and blood vessels in Kimura's disease (p<0.01) compared with normal skin and reactive lymph node controls. However, as far as the individual Kimura's disease lesion is concerned, there was generally no correlation between areas with mast cell increase and the degree of vascularity. Moreover, when lesions of less than 1 year's duration were compared with older lesions, there appeared to be a relative decrease in mast cells and a concomitant increase in vascularity in the latter. These results confirmed that mast cells are associated with Kimura's disease, and suggest that they may be involved in its early pathogenesis, although its possible role in angiogenesis may not be direct.
在对VIII因子相关抗原进行免疫组织化学染色并用甲苯胺蓝复染后，采用定量方法研究了肥大细胞与木村病典型病变的关系。对9例确诊的木村病病例的福尔马林固定、石蜡包埋组织切片进行染色后检查，通过在油镜下计数100个随机视野来估计肥大细胞和血管密度。与正常皮肤和反应性淋巴结对照相比，木村病中的肥大细胞和血管均有统计学意义的增加（p<0.01）。然而，就单个木村病病变而言，肥大细胞增加的区域与血管化程度之间通常没有相关性。此外，将病程小于1年的病变与较老的病变进行比较时，后者似乎肥大细胞相对减少，血管化程度相应增加。这些结果证实肥大细胞与木村病相关，并表明它们可能参与其早期发病机制，尽管其在血管生成中的可能作用可能不是直接的。
