Prausnitz M R, Noonan J S
School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332-0100, USA.
J Pharm Sci. 1998 Dec;87(12):1479-88. doi: 10.1021/js9802594.
The objective of this study was to collect a comprehensive database of ocular tissue permeability measurements found in a review of the literature to guide models for drug transport in the eye. Well over 300 permeability measurements of cornea, sclera, and conjunctiva, as well as corneal epithelium, stroma, and endothelium, were obtained for almost 150 different compounds from more than 40 different studies. In agreement with previous work, the corneal epithelium was shown generally to control transcorneal transport, where corneal stroma and endothelium contribute significantly only to the barrier for small, lipophilic compounds. In addition, other quantitative comparisons between ocular tissues are presented. This study provides an extensive database of ocular tissue permeabilities, which should be useful for future development and validation of models to predict rates of drug delivery to the eye.
本研究的目的是收集文献综述中发现的眼部组织通透性测量的综合数据库，以指导眼部药物转运模型。从40多项不同研究中获取了近150种不同化合物的300多项角膜、巩膜和结膜以及角膜上皮、基质和内皮的通透性测量数据。与先前的研究一致，角膜上皮通常被证明控制着跨角膜转运，其中角膜基质和内皮仅对小的亲脂性化合物的屏障有显著贡献。此外，还给出了眼部组织之间的其他定量比较。本研究提供了一个广泛的眼部组织通透性数据库，这对于预测药物眼部递送速率模型的未来开发和验证应该是有用的。
