Semple D, Russell S, Doyle E, Aldridge L M
Department of Anaesthesia, Royal Hospital for Sick Children, Edinburgh, UK.
Paediatr Anaesth. 1999;9(2):135-8. doi: 10.1046/j.1460-9592.1999.9220317.x.
We undertook a double-blind study to evaluate equianalgesic doses of intramuscular morphine sulphate (0.15 mg.kg-1) and codeine phosphate (1.5 mg.kg-1) in 40 healthy children undergoing adenotonsillectomy. There were no significant differences in pain scores, analgesic requirements or sedation scores between the two groups over the following 24 h. More children vomited in the morphine group (60%) than the codeine group (30%) between one and six h after the procedure (P < 0.05). Codeine phosphate is associated with less postoperative vomiting than morphine sulphate while providing comparable postoperative analgesia for adenotonsillectomy.
我们进行了一项双盲研究，以评估40名接受腺扁桃体切除术的健康儿童中，肌肉注射硫酸吗啡（0.15毫克·千克-1）和磷酸可待因（1.5毫克·千克-1）的等效镇痛剂量。在接下来的24小时内，两组之间的疼痛评分、镇痛需求或镇静评分没有显著差异。术后1至6小时内，吗啡组呕吐的儿童（60%）多于可待因组（30%）（P<0.05）。磷酸可待因与术后呕吐少于硫酸吗啡有关，同时为腺扁桃体切除术提供了相当的术后镇痛效果。
