Wirnsberger R M, De Vries J, Jansen T L, Van Heck G L, Wouters E F, Drent M
Department of Pulmonology, University Hospital, Maastricht, The Netherlands.
Neth J Med. 1999 Mar;54(3):86-95. doi: 10.1016/s0300-2977(98)00148-x.
Quality of life (QOL) has become an important item in health care. QOL should be a major target of treatment in chronic diseases such as rheumatoid arthritis (RA) and sarcoidosis. The aim of this study was to compare the impact of RA and sarcoidosis on patients' QOL. We expected more serious impairment of QOL in the RA group than in the sarcoidosis group.
QOL was studied in RA patients (n = 32), sarcoidosis patients (n = 37), and a healthy control group (n = 37) employing the World Health Organization Quality of Life assessment instrument (WHOQOL-100).
In both patient groups QOL was impaired with respect to Physical Health, Level of Independence (P < 0.001), and Overall QOL and General Health (P < 0.01). Moreover, RA patients appeared to have a lower QOL with respect to Pain and Discomfort (P < 0.001) and Mobility (P < 0.001).
In RA and sarcoidosis, fatigue and sleep were major problems. In contrast to our expectations, with respect to activities of daily living and working capacity, the two patient groups did not show any difference. Impairment of QOL was more serious and included more aspects of QOL in RA than in sarcoidosis.
生活质量（QOL）已成为医疗保健中的一个重要项目。生活质量应是类风湿关节炎（RA）和结节病等慢性疾病治疗的主要目标。本研究的目的是比较RA和结节病对患者生活质量的影响。我们预计RA组的生活质量受损程度会比结节病组更严重。
采用世界卫生组织生活质量评估工具（WHOQOL - 100）对32例RA患者、37例结节病患者和37例健康对照组进行生活质量研究。
在两个患者组中，身体健康、独立水平（P < 0.001）、总体生活质量和一般健康状况（P < 0.01）方面的生活质量均受损。此外，RA患者在疼痛与不适（P < 0.001）和活动能力（P < 0.001）方面的生活质量似乎更低。
在RA和结节病中，疲劳和睡眠是主要问题。与我们的预期相反，在日常生活活动和工作能力方面，两个患者组没有显示出任何差异。RA患者生活质量的受损更严重，且涉及生活质量的更多方面。
