Wirnsberger R M, de Vries J, Breteler M H, van Heck G L, Wouters E F, Drent M
Department of Pulmonology, University Hospital Maastricht, The Netherlands.
Respir Med. 1998 May;92(5):750-6. doi: 10.1016/s0954-6111(98)90007-5.
Health-related quality of life (QOL) has become an important topic in health care. However, hardly any attention has been paid to QOL in sarcoidosis. Therefore, the aim of this study was to assess the impact of sarcoidosis on QOL. Sixty-four sarcoidosis patients completed the World Health Organization Quality of Life assessment instrument (WHOQOL-100) and the Beck Depression Inventory (BDI). For the WHOQOL-100 a matched group of healthy controls was selected. Patients were divided into two groups: group I (n = 37) consisted of patients with actual symptoms, group II (n = 27) consisted of asymptomatic patients. The WHOQOL-100 revealed a number of areas in which sarcoidosis patients, especially those with current symptoms, experienced problems. A major symptom in both groups of sarcoidosis patients was fatigue. No association between the facet fatigue and the domain psychological health was found. Depressive symptoms (BDI) were associated with psychological function (WHOQOL-100). No association between pulmonary function tests and QOL was found. In conclusion, this study shows that sarcoidosis has a considerable impact on the QOL of patients. The WHOQOL-100 appeared to be a sensitive instrument to measure fatigue--one of the most common symptoms in sarcoidosis--which otherwise is difficult to assess objectively.
与健康相关的生活质量（QOL）已成为医疗保健领域的一个重要话题。然而，结节病患者的生活质量几乎未受到任何关注。因此，本研究的目的是评估结节病对生活质量的影响。64名结节病患者完成了世界卫生组织生活质量评估工具（WHOQOL - 100）和贝克抑郁量表（BDI）。对于WHOQOL - 100，选取了一组匹配的健康对照。患者被分为两组：第一组（n = 37）由有实际症状的患者组成，第二组（n = 27）由无症状患者组成。WHOQOL - 100揭示了结节病患者，尤其是有当前症状的患者，在多个方面存在问题。两组结节病患者的一个主要症状是疲劳。未发现疲劳方面与心理健康领域之间存在关联。抑郁症状（BDI）与心理功能（WHOQOL - 100）相关。未发现肺功能测试与生活质量之间存在关联。总之，本研究表明结节病对患者的生活质量有相当大的影响。WHOQOL - 100似乎是一种测量疲劳的敏感工具，疲劳是结节病最常见的症状之一，否则很难进行客观评估。
