Jacobowitz D M
Laboratory of Clinical Science, NIMH, Bethesda, Maryland 20892, USA.
Nihon Yakurigaku Zasshi. 1998 Oct;112 Suppl 1:1P-4P. doi: 10.1254/fpj.112.supplement_1.
Neuropeptides have now been localized throughout the nervous system. This talk focuses attention on (1) the interplay of peptides and other neurotransmitter systems in the hypothalamus--median eminence--pituitary gland. The multiplicity of neurochemicals is perceived to be responsible for the integrated control of pituitary hormone releasing factors; (2) the role of neuropeptides in the regulation of cardiovascular function in the hypothalamus-preoptic area. We investigated the effects of discrete intrahypothalamic injections of a variety of peptides on blood pressure and heart rate. We concluded that neuropeptides have a diversity of central cardiovascular actions and that not all areas containing a given peptide respond with cardiovascular change when the peptide is injected. Also, peptide specific actions originating within the same nucleus have been demonstrated, and the same peptide may have different vascular effects in different segments of the same nucleus; (3) the colocalization of neuropeptides with other classical neurotransmitters. We have found modulatory behavioral effects ("boxing") of combinations of transmitters and peptides injected into the postsynaptic site in the brain.
神经肽现已在整个神经系统中定位。本次讲座重点关注：（1）下丘脑-正中隆起-垂体腺中肽与其他神经递质系统的相互作用。多种神经化学物质被认为负责垂体激素释放因子的综合控制；（2）神经肽在下丘脑-视前区心血管功能调节中的作用。我们研究了向下丘脑不同部位注射多种肽对血压和心率的影响。我们得出结论，神经肽具有多种中枢心血管作用，当注射肽时，并非所有含有特定肽的区域都会出现心血管变化。此外，已证明源自同一核内的肽具有特异性作用，并且同一肽在同一核的不同节段可能具有不同的血管效应；（3）神经肽与其他经典神经递质的共定位。我们发现将递质和肽的组合注入大脑突触后部位会产生调节性行为效应（“拳击”）。
