Zhang C Y, Tan B K
Department of Pharmacology, Faculty of Medicine, National University of Singapore.
Phytother Res. 1999 Mar;13(2):157-9. doi: 10.1002/(SICI)1099-1573(199903)13:2<157::AID-PTR388>3.0.CO;2-B.
14-deoxyandrographolide (DA) and 14-deoxy-11,12-didehydroandrographolide (DDA) are two diterpenoids isolated from A. paniculata, a popular folk medicine used as an antihypertensive drug in Malaysia. We have previously reported that DDA exhibited a greater hypotensive effect in anaesthetized rats and a vasorelaxant activity in isolated rat aorta, compared with DA. Their vasorelaxant activities were mediated through the activation of the enzymes, nitric oxide synthase (NOS) and guanylyl cyclase. The present study demonstrated that both DA and DDA stimulated nitric oxide (NO) release from human endothelial cells. DDA compared with DA caused a greater production of NO; this is in line with the finding of the earlier study that the vasorelaxant effect of DDA was more dependent on endothelium than DA.
14 - 去氧穿心莲内酯（DA）和14 - 去氧 - 11,12 - 二脱氢穿心莲内酯（DDA）是从穿心莲中分离出的两种二萜类化合物，穿心莲是一种在马来西亚用作抗高血压药物的常用民间药物。我们之前报道过，与DA相比，DDA在麻醉大鼠中表现出更大的降压作用，在离体大鼠主动脉中具有血管舒张活性。它们的血管舒张活性是通过激活一氧化氮合酶（NOS）和鸟苷酸环化酶介导的。本研究表明，DA和DDA均能刺激人内皮细胞释放一氧化氮（NO）。与DA相比，DDA能产生更多的NO；这与早期研究结果一致，即DDA的血管舒张作用比DA更依赖于内皮。
