1976 - 1995年德国萨尔州卵巢癌患者的生存趋势。
Trends in survival of patients with ovarian cancer in Saarland, Germany, 1976-1995.
作者信息
Brenner H, Stegmaier C, Ziegler H
机构信息
University of Ulm, Department of Epidemiology, Germany.
出版信息
J Cancer Res Clin Oncol. 1999;125(2):109-13. doi: 10.1007/s004320050250.
PURPOSE
We aimed to monitor recent progress in survival of patients with ovarian cancer.
METHODS
We assessed trends in survival in 1976-1995 among patients notified to the population-based cancer registry of Saarland, Germany, with a first diagnosis of ovarian cancer below the age of 80 years. A new statistical methodology was applied that allows the most timely detection of changes in survival rates.
RESULTS
There was a dramatic, ongoing increase in 5-year relative survival rates from 36.6% in 1976-1980 to 60.1% in 1991-1995 among patients whose cancer was detected below the age of 55 years, and from 23.7% to 42.9% in patients aged 55-64 years at the time of diagnosis. No such improvement was seen among older patients, who continued to have a very poor prognosis. Therefore, the variation of prognosis with age was strongly increasing over time.
CONCLUSIONS
Improvement of prognosis in younger patients most likely reflects the benefits of more aggressive surgery and chemotherapy in these age groups. Efforts should be made to overcome obstacles to more successful therapy for older patients.
目的
我们旨在监测卵巢癌患者生存率的近期进展。
方法
我们评估了1976年至1995年间首次诊断为卵巢癌且年龄在80岁以下、向德国萨尔州基于人群的癌症登记处报告的患者的生存趋势。应用了一种新的统计方法，该方法能够最及时地检测生存率的变化。
结果
在癌症确诊时年龄低于55岁的患者中，5年相对生存率从1976 - 1980年的36.6%显著持续上升至1991 - 1995年的60.1%；在确诊时年龄为55 - 64岁的患者中，这一比例从23.7%上升至42.9%。老年患者未见此类改善，其预后仍然很差。因此，随着时间推移，预后随年龄的差异在显著增加。
结论
年轻患者预后的改善很可能反映了这些年龄组中更积极的手术和化疗的益处。应努力克服老年患者更成功治疗的障碍。
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