Kayikçioğlu M, Ozerkan F, Soydan I
Department of Cardiology, Ege University Medical School, Izmir, Turkey.
Am J Cardiol. 1999 Apr 1;83(7):1135-7, A9. doi: 10.1016/s0002-9149(99)00030-2.
This randomized prospective clinical study evaluated the lipid-lowering effects and safety of a new combination regimen in patients with mixed hyperlipidemia. The data show that alternate-day simvastatin and fenofibrate therapy was as effective as the standard daily combination of the same drugs at the same doses, and it was safer, less expensive, and more tolerable.
这项随机前瞻性临床研究评估了一种新的联合治疗方案对混合性高脂血症患者的降脂效果和安全性。数据表明,隔日服用辛伐他汀和非诺贝特的疗法与相同剂量的相同药物标准每日联合用药效果相同,且更安全、成本更低、耐受性更好。