Dale M, Nicklin M J
Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2JF, United Kingdom.
Genomics. 1999 Apr 1;57(1):177-9. doi: 10.1006/geno.1999.5767.
The family of interleukin-1 receptor-like genes currently has six known members. We have constructed a contig of 10 overlapping human PAC clones that covers 530 kb and includes five of the six family members. The termini of the contig were mapped to the interval between D2S373 and D2S176 (chromosome 2q12) by radiation hybrid mapping. The contig contains the genes (cen --> tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the IL-1 receptor-related protein 1, which has recently been shown to be a component of the IL-18 receptor (IL18R1). We show that all the genes are transcribed in the same direction, with IL1R2 being transcribed toward the cluster. The only known family member that is absent from the human contig is the IL-1 receptor accessory protein gene (IL1RAP), which maps to 3q28.
白细胞介素-1受体样基因家族目前已知有六个成员。我们构建了一个由10个重叠的人类PAC克隆组成的重叠群，其覆盖530 kb，包含六个家族成员中的五个。通过辐射杂种图谱分析，将该重叠群的末端定位到D2S373和D2S176（染色体2q12）之间的区间。该重叠群按顺序（着丝粒→端粒）包含以下基因：Ⅱ型白细胞介素-1（IL-1）受体（IL1R2）、Ⅰ型IL-1受体（IL1R1）、IL-1受体相关蛋白2（IL1RL2）、T1/ST2/fit-1（IL1RL1）以及IL-1受体相关蛋白1，最近已证明它是IL-18受体（IL18R1）的一个组成部分。我们发现所有基因都按相同方向转录，其中IL1R2朝着该基因簇转录。人类重叠群中唯一缺失的已知家族成员是白细胞介素-1受体辅助蛋白基因（IL1RAP），它定位于3q28。
