高甲胎蛋白和孕妇吸烟对胎儿发育的影响。
The effects on fetal development of high alpha-fetoprotein and maternal smoking.
作者信息
Heinonen S, Ryynänen M, Kirkinen P
机构信息
Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland.
出版信息
Am J Public Health. 1999 Apr;89(4):561-3. doi: 10.2105/ajph.89.4.561.
OBJECTIVES
This study determined the risk of impaired fetal growth resulting from the interaction between maternal smoking during pregnancy and unexplained elevated concentrations of maternal serum alpha-fetoprotein (MSAFP).
METHODS
This observational study involved 123 pregnant smokers with unexplained second-trimester elevated concentrations of MSAFP, 827 smokers with normal levels, and 471 nonsmokers with raised levels.
RESULTS
By logistic regression, coincident smoking and elevated MSAFP levels were found to be associated with increases in the low basic risks of prematurity, small-for-gestational-age births, low birthweight, and need for neonatal care.
CONCLUSIONS
Maternal smoking has an adverse effect on fetal development in pregnancies with unexplained elevated MSAFP concentrations. Such pregnancies merit close surveillance.
目的
本研究确定孕期母亲吸烟与原因不明的母亲血清甲胎蛋白（MSAFP）浓度升高之间的相互作用导致胎儿生长受限的风险。
方法
这项观察性研究纳入了123名孕期吸烟且孕中期MSAFP浓度原因不明升高的孕妇、827名MSAFP水平正常的吸烟者以及471名MSAFP水平升高的非吸烟者。
结果
通过逻辑回归分析，发现吸烟与MSAFP水平升高同时出现与早产、小于胎龄儿出生、低出生体重以及新生儿护理需求等低基础风险增加有关。
结论
在MSAFP浓度原因不明升高的妊娠中，母亲吸烟对胎儿发育有不良影响。此类妊娠值得密切监测。
Zotero 插件