Li D K, Wi S
Division of Research, Kaiser Foundation Research Institute, California Region, Oakland 94611, USA.
Am J Epidemiol. 1999 Apr 1;149(7):608-11. doi: 10.1093/oxfordjournals.aje.a009860.
To determine whether placental abnormality (placental abruption or placental previa) during pregnancy predisposes an infant to a high risk of sudden infant death syndrome (SIDS), the authors conducted a population-based case-control study using 1989-1991 California linked birth and death certificate data. They identified 2,107 SIDS cases, 96% of whom were diagnosed through autopsy. Ten controls were randomly selected for each case from the same linked birth-death certificate data, matched to the case on year of birth. About 1.4% of mothers of cases and 0.7% of mothers of controls had either placental abruption or placenta previa during the index pregnancy. After adjustment for potential confounders, placental abnormality during pregnancy was associated with a twofold increase in the risk of SIDS in offspring (odds ratio = 2.1, 95% confidence interval 1.3-3.1). The individual effects of placental abruption and placenta previa on the risk of SIDS did not differ significantly. An impaired fetal development due to placental abnormality may predispose an infant to a high risk of SIDS.
为确定孕期胎盘异常（胎盘早剥或前置胎盘）是否会使婴儿患婴儿猝死综合征（SIDS）的风险升高，作者利用1989 - 1991年加利福尼亚州出生与死亡证明关联数据开展了一项基于人群的病例对照研究。他们识别出2107例SIDS病例，其中96%通过尸检确诊。从相同的出生 - 死亡证明关联数据中为每个病例随机选取10名对照，对照与病例按出生年份匹配。约1.4%的病例母亲和0.7%的对照母亲在本次妊娠期间发生了胎盘早剥或前置胎盘。在对潜在混杂因素进行调整后，孕期胎盘异常与子代患SIDS风险增加两倍相关（比值比 = 2.1，95%置信区间1.3 - 3.1）。胎盘早剥和前置胎盘对SIDS风险的个体影响无显著差异。胎盘异常导致的胎儿发育受损可能使婴儿患SIDS的风险升高。
