New chemotherapeutic agent for root canal treatment. A preliminary electron microscopic study on an in vivo and in vitro endodontically treated tooth.

A preliminary in vivo and in vitro electron microscopic study of root canals treated endodontically with EDTA-C and Salvizol proved the latter to be superior as a chemomechanical and irrigation solution, especially in the apical third of the roots. A further virtue of Salvizol, as has been demonstrated, is its capability to dissolve the organic matrix of dentin, thus exposing the mineralizing front and the patent tubules even in the apical third of the canal. The combined properties of Salvizol which introduce it as a chemotherapeutic agent for endodontics are: (1) broad spectrum of bactericidal activity, (2) ability to dissolve calcium, (3) neutral pH, (4) cleansing potency, and (5) biologic compatibility.