Tang G, Jiang S, Gu N, Jin T, Lin S, Qian Y, Wang D, Zhang M
Shanghai Institute of Mental Health. Shanghai, 200030, P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Apr;16(2):94-6.
To detect the relation between alpha1-antichymotrpsin(AACT)gene polymorphism and epsilon4 allele of apolipoprotein E (ApoE) gene in Alzheimer disease (AD) in Chinese.
The gene polymorphisms of ApoE and AACT were genotyped in 125 AD cases and 140 controls with PCR methods and RFLP typing. Then the association between AACT polymorphism and ApoE epsilon4 was analysed.
There was no association between AD and any allele or genotype of AACT polymorphism; AACT polymorphism was not associated with AD ApoE epsilon4 or without ApoE epsilon4. In AACTAT and AACTTT genotypes, ApoE epsilon4 allele was associated with AD, but no association was observed in AACT*AA genotype.
AACT may not be associated with AD in Chinese, and this effect can not be influenced by ApoE epsilon4, but AACT gene polymorphism may affect the association between ApoE epsilon4 allele and AD.
检测中国人群中阿尔茨海默病（AD）患者α1-抗糜蛋白酶（AACT）基因多态性与载脂蛋白E（ApoE）基因ε4等位基因之间的关系。
采用聚合酶链反应（PCR）方法和限制性片段长度多态性（RFLP）分型技术，对125例AD患者和140例对照者的ApoE和AACT基因多态性进行基因分型。然后分析AACT多态性与ApoE ε4之间的关联。
AD与AACT多态性的任何等位基因或基因型之间均无关联；AACT多态性与AD患者有无ApoE ε4均无关联。在AACTAT和AACTTT基因型中，ApoE ε4等位基因与AD相关，但在AACT*AA基因型中未观察到关联。
在中国人群中，AACT可能与AD无关，且这种影响不受ApoE ε4的影响，但AACT基因多态性可能影响ApoE ε4等位基因与AD之间的关联。
