Jakobsson J, Dahlgren G, Oddby E, Ryberg G
Department of Anaesthesia, Sabbatsberg Närsjukhuset, Sweden.
J Laparoendosc Adv Surg Tech A. 1999 Feb;9(1):51-5. doi: 10.1089/lap.1999.9.51.
The authors studied the incidence of postoperative nausea and vomiting (PONV) and the effect of prophylactic tropisetron, a 5-HT3 antagonist, during the first 24 h following elective gynecologic laparoscopic surgery. Thirty-two of 68 (47%) of the patients experienced nausea or vomiting some time during the observation period. Sixteen of the 32 PONV patients (50%) had their first emetic symptoms after discharge from the recovery room. We could see no difference in the frequency of PONV in the patients who were given prophylactic tropisetron 5 mg orally before anesthesia.
作者研究了择期妇科腹腔镜手术后24小时内术后恶心呕吐（PONV）的发生率以及预防性使用5-羟色胺3（5-HT3）拮抗剂托烷司琼的效果。68例患者中有32例（47%）在观察期内的某个时间出现恶心或呕吐。32例PONV患者中有16例（50%）在从恢复室出院后出现首次呕吐症状。我们发现，在麻醉前口服5毫克预防性托烷司琼的患者中，PONV的发生率没有差异。
